Quad by MEDVi.
The 4-in-1, reviewed.
A compounded multi-active ED formula combining four FDA-approved generic ingredients in a single prescription. Here's what it actually is, how the pricing breaks down, and whether it matches the claims.
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Why a multi-active formula is different.
Most ED telehealth products prescribe a single active ingredient — usually a PDE5 inhibitor like sildenafil or tadalafil. Quad combines four. Three are PDE5 inhibitors (blood-flow pathway), one acts on the central nervous system (the desire pathway). According to MEDVi, this is the first compounded formulation to combine both mechanisms in a single prescription.
Source: MEDVi product listing via Katalys, April 2026. All four actives are individually FDA-approved generic medicines.
Dopamine agonist. Acts centrally on the brain's desire pathway — the only non-PDE5 active.
PDE5 inhibitor. Generic form of a well-established blood-flow active. Half-life ~4–5 hrs.
PDE5 inhibitor. The most studied oral ED active. Onset 30–60 min, half-life 4 hrs.
PDE5 inhibitor. Long half-life (17.5 hrs) — why Quad offers a 36-hour response window.
Intake. Review. Arrive.
Online questionnaire covering medical history, current medications, and cardiovascular risk. Reviewed by a licensed clinician in your state.
If appropriate, a licensed clinician issues a prescription. Not guaranteed — prescriptions reflect clinical judgment.
Partner pharmacy compounds the four-active formulation. Free rush shipping. Plain packaging. Cancel anytime.
Includes doctor consultation, medication, and free rush shipping. Cancel anytime.
| Option | Price (public) |
|---|---|
| Quad by MEDVi | $119/mo |
| Generic PDE5 (pharmacy) | $30–$50 / 10 + Rx |
| Brand-name ED (pharmacy) | $70–$90 / pill |
US pharmacy retail pricing, April 2026. Individual out-of-pocket varies. Not interchangeable — context only.
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Is Quad FDA-approved?+
The four active ingredients in Quad are individually FDA-approved generic medicines. Compounded formulations — combinations prepared by a licensed pharmacy per a specific prescription — are regulated under Section 503A of the Federal Food, Drug, and Cosmetic Act. Compounded medications are not FDA-approved in the same way as mass-manufactured drugs; they are prepared for a specific patient based on a prescriber's judgment.
Is a prescription required?+
Yes. A licensed clinician in your state reviews your medical intake and issues a prescription only if appropriate. Quad cannot be purchased over the counter.
What states is this available in?+
Quad by MEDVi is available in all 50 US states, per their current listing. Clinician licensure and pharmacy shipping are managed within the service.
Can I cancel?+
Yes. Per MEDVi, the subscription is cancel-anytime with no long-term commitment.
Does insurance cover this?+
Compounded prescription formulations are generally not covered by commercial insurance in the US. The $119/month price is cash-pay. This is typical for compounded telehealth.
How is this different from Hims, Ro, or BlueChew?+
Most large ED telehealth providers prescribe a single-active generic (sildenafil OR tadalafil). Quad combines four actives — three PDE5 inhibitors plus apomorphine — in one compounded prescription. This is the primary product distinction.
Quad by MEDVi is the first compounded ED telehealth formulation to combine four actives across two mechanisms. That's the reason you'd pay the premium. If a single-active generic has already worked for you, it's probably not for you. If it hasn't, it's worth a look.
See Quad by MEDVi.
$119/per month · 4-ingredient formula · Doctor consultation included · Cancel anytime.
Visit Quad by MEDVi →We earn a commission when you sign up for Quad by MEDVi through links on this page. Our review is editorial and independent — see our review policy below.